Sepsis Australia continues to make significant contributions to the global momentum on sepsis through its management and coordination of the Asia Pacific Sepsis Alliance (APSA) and membership of the Global Sepsis Alliance (GSA) Executive Board, a WHO advisor on sepsis.
The 2030 Global Agenda for Sepsis is the first multi-year strategic vision aimed at alleviating the significant human, societal, healthcare and economic burden of Sepsis and its sequelae through concerted efforts of UN Member States and multiple stakeholders at national, regional and global levels.
The Global Sepsis Alliance (GSA) initiated and coordinated the development of this document with the engagement of its five Regional Sepsis Alliances, and over 70 member and partner organisations from Africa, Asia-Pacific, the Caribbean, Eastern Mediterranean, Europe, Latin America, and North America. The multi-stakeholder strategic dialogue started in 2023 on the margins of the 78th Session of the UN General Assembly in New York, followed by sepsis side events in parallel to the 2023 World Health Summit in Berlin and the 77th Session of the World Health Assembly in Geneva in 2024.
The ultimate goal of the 2030 Global Agenda is to avert millions of preventable deaths and disabilities among children, women, and men by stronger positioning of Sepsis in the global health and development architecture and enhancing response capacities to this medical emergency in community and healthcare settings. The strategy aims at reducing the global incidence of Sepsis by at least 25%, improving the survival rates of paediatric and adult patients by over 20%, and reducing the median cost per Sepsis patient per country by 20% from 2017-2020 baselines.
Read more and download the agenda at: 2030 Global Agenda for Sepsis
In February 2025, the Global Sepsis Innovations Platform (GSIP) was launched. GSIP aims to foster coordinated discussions and advocacy to address unmet needs in Sepsis R&D for novel vaccines, other prevention interventions, diagnostics, antimicrobial and immunomodulatory therapies, precision medicine, care and rehabilitation, and AI technologies. The five main objectives of GSIP are:
- Knowledge Exchange: Facilitating collaboration among innovators, researchers, healthcare professionals, Sepsis survivors, and patients’ families.
- Regulatory Collaboration: Engaging in consensus-building discussions and formulating recommendations and position statements for sepsis innovation authorization.
- Advocacy Coordination: Working with governments, foundations, industry, and research institutions to increase investments in Sepsis R&D.
- Operational Research Coordination: Addressing accessibility and affordability of Sepsis-related equipment and supplies, especially in low- and middle-income countries (LMICs).
- Defining Sepsis R&D Agenda: Identifying critical research priorities, especially for LMICs, including vaccines, early detection and treatment strategies, and AI solutions.
Read more and get involved in GSIP at: Global Sepsis Alliance News
For more news on the global momentum see: Global Sepsis Alliance
Nations across the Asia Pacific are collaborating on activities, strategies and research through the APSA network. One of APSA’s landmark achievements is the publication of guidance for sepsis management in low-resource settings, released in December 2024. This guidance, developed through a global Delphi study, represents a consensus of international experts and provides actionable solutions to address challenges in under-resourced healthcare environments (Ref: Thwaites, L., Nasa, P., Abbenbroek, B., et al. Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method. Intensive Care Med 51, 21–38, 2025).
In 2025, APSA will undertake a Regional Global Burden of Disease sub-study, utilising data from the Institute for Health Metrics and Evaluation (IHME), pending the finalisation of a memorandum of understanding (MoU) and the release of new Global Burden of Disease data on Sepsis.
Sepsis Australia is also actively contributing to the development and implementation of Sepsis National Action Plans. By providing a detailed template and expert guidance for building consensus, the organisation is helping countries across the region improve their strategic response to sepsis. A regional stocktake and quality appraisal of these action plans are underway to ensure their effectiveness and alignment with global best practices.
Through these initiatives, Sepsis Australia delivers on its commitment to advancing sepsis prevention, treatment, and policy on a global scale underscoring the importance of international collaboration in addressing this life-threatening condition and improving outcomes for affected individuals worldwide.
Read more about APSA and get involved at: Asia Pacific Sepsis Alliance